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Selank (Synthetic Tuftsin Analog): Neuropeptide & Neuroimmune Research Peptide

Product Specifications

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro Untitled document (11)
• Molecular Weight: ~863 Da
• Purity: ≥99% (HPLC verified) Untitled document (11)
• Solubility: Sterile water or PBS
• Storage: −20°C, protected from light and moisture
• Use: For Research Use Only. Not for human or veterinary use

Description

Selank is a synthetic heptapeptide engineered from the naturally occurring immunomodulatory molecule tuftsin, a fragment derived from the IgG heavy chain. As a research compound, it occupies a unique position in modern neuroscience because it sits at the intersection of neurotransmitter regulation, gene-expression dynamics, and immune-system signaling, making it one of the most versatile neuropeptides available to laboratories.

Structurally simple, just seven amino acids, yet functionally far-reaching, Selank offers researchers a consistent and highly reproducible model for studying neurochemical balance, stress adaptation, and psychoneuroimmunology. Its high purity (≥99%, HPLC verified) and stability make it well-suited for controlled in-vitro and in-vivo laboratory systems.

What distinguishes Selank from many classical neuropeptides is its dual-domain mechanism: it simultaneously affects both neural and immune pathways. In neurobiological systems, it modulates GABAergic transmission, stabilizing inhibitory tone and altering receptor response patterns. This is complemented by its influence on serotonergic circuits, where studies have documented shifts in gene transcription associated with serotonin synthesis and receptor regulation. Such dual modulation gives this peptide an important role in research on emotional regulation, inhibitory control, and behavioral neuroadaptation, areas where both neurotransmitters operate in synchrony.

Selank also exerts measurable effects on neurotrophic factors such as BDNF, along with transcription markers that relate to synaptic plasticity and cognitive processing. These gene-level shifts allow researchers to examine how small peptides can modulate the nervous system without directly interacting with classical receptor sites, an emerging trend in peptide neurobiology.

On the immune side, Selank is equally intriguing. Multiple studies have shown that the peptide modulates key cytokines including IL-6, IL-10, and TNF-α, placing it at the center of research into the stress–immune axis. This positions it as a valuable tool for psychoneuroimmunology, enabling investigations into how psychological stress, infection, or inflammation influences neural function. In many experiments, it provides a bridge between immune signaling and neurochemical adaptation, allowing researchers to observe the two systems in tandem.

Comparison: Selank vs Semax

Although Selank and Semax are often grouped as “regulatory neuropeptides,” they originate from entirely different biological families and therefore behave differently in research settings. It’s a tuftsin analog, inherited from immune-system signaling, while Semax is an ACTH(4-10) analog, originating from endocrine stress pathways.

This peptide primarily influences GABA/serotonin balance and cytokine regulation, whereas Semax focuses more on BDNF expression, neuroprotection, and metabolic resilience. Both inhibit certain enkephalin-degrading enzymes, but through distinct structural domains. The two peptides complement each other but are not interchangeable.

Comparison: Standard Selank vs N-Acetyl / C-Amidated Selank

Modern laboratories now work with two major Selank variants: the standard acetate form, which preserves natural terminal charges, and the N-acetyl/C-amidated form, which neutralizes these charges. The capped form is more resistant to exopeptidases and displays higher lipophilicity, making it useful for membrane-crossing and stability studies. However, the unmodified form remains the reference standard used in most published literature.

Overall, it’’s multi-pathway activity, stability, and predictable performance make it a cornerstone reagent for laboratories studying inhibitory neurotransmission, gene expression, immune regulation, and neurobehavioral adaptation.

Scientific Research Areas

• Neurotransmitter Regulation
  Selank modulates GABAergic and serotonergic pathways, stabilizing inhibitory tone and influencing gene expression associated with synaptic plasticity.
• Neuroimmune Modulation
  Research models show Selank adjusts IL-6, IL-10, and TNF-α levels, helping scientists explore stress-immune communication and psychoneuroimmunology.
• Gene Expression & Neurotrophic Factors
  Studies document activity involving BDNF-related signaling and transcriptional changes relevant to neural adaptation and plasticity.
• Stress & Behavioral Biology
  Selank is widely used in controlled laboratory systems investigating stress-response pathways, inhibitory control, and emotional-behavioral regulation.

Research Applications

Selank is used in controlled laboratory environments for:

• GABAergic and serotonergic pathway studies
• Gene-expression and neurotrophic signaling models
• Cytokine and neuroimmune interaction research
• Stress, behavior, and adaptation biology
• Neuropeptide structural-variant comparisons (Selank vs Semax)
• Peptide stability and terminal-modification assays (acetate vs capped)

Features / Highlights

• Supports neurotransmitter and neuroimmune research
• Synthetic tuftsin analog with well-characterized activity
• ≥99% purity, HPLC verified for reproducibility
• Studied for gene expression, stress modeling, and cytokine pathways
• Available in standard and N-acetyl/amidated research variants
• Strictly for Research Use Only (RUO)